What Are CMS' Part B Rebatable Drugs for 2025?

We’ve got the Centers for Medicare & Medicaid Services’ (CMS) most recent list of Medicare Part B drugs your clients may pay reduced coinsurance for from October through December 2025!

CMS publishes the Medicare Part B rebatable drugs quarterly. Keep reading to see the latest Part B rebate guidance.

Inflation-Adjusted Coinsurances for Medicare Part B Drugs

As a reminder, Medicare Part B generally covers drugs provided in doctors’ offices and hospital outpatient departments. Part B drugs may qualify for price adjustments as a result of the Medicare Prescription Drug Inflation Rebate provision in the Inflation Reduction Act (IRA).

The provision states that drug manufacturers who increase the prices of their drugs faster than the rate of inflation must reimburse Medicare for the difference. The reimbursement comes in the form of a rebate, hence the name “Part B rebatable drugs.” CMS then passes the savings back to Medicare enrollees through inflation-adjusted Part B coinsurances.

In December 2024, CMS reported that Medicare beneficiaries have seen savings on more than 120 drugs thanks to the IRA’s Medicare Part B inflation rebate program.

Part B Drugs Eligible for Reduced Coinsurance in 2025

Recently, CMS published their October 2025 ASP Pricing File, noting the 82 Part B prescription drugs that may have lower beneficiary coinsurance rates for October, November, and December due to their prices increasing faster than inflation.

Note: CMS released information on inflation-adjusted coinsurances via their quarterly Average Sales Price (ASP) public files. Occasionally, CMS updates these after they release them, before the changes go into effect.

Q4 2025 Part B Rebatable Drugs

DrugInflation-Adjusted Coinsurance
Percentage (Normally 20%)
Inj., eravacycline, 1 mg19.177
Inj, amiodarone (nexterone)11.746
Inj, rezafungin, 1 mg19.872
Inj, abilify maintena, 1 mg19.943
Peng benzathine/procaine inj15.127
Penicillin g benzathine inj12.418
Injection, burosumab-twza 1m18.696
C-1 esterase, berinert18.589
Canakinumab injection19.992
Inj ceftolozane tazobactam17.956
Collagenase, clost hist inj17.579
Injection, imetelstat, 1 mg19.839
Denosumab injection17.508
Digoxin immune fab (ovine)19.592
Inj tofersen intrathec 1 mg19.861
Elosulfase alfa, injection19.874
Inj, fosaprepitant (teva)7.906
Galsulfase injection19.840
Hizentra injection19.217
Inj, panzyga, 500 mg18.554
Hemin, 1 mg18.975
Dalteparin sodium12.798
Ibuprofen injection19.709
Inj., ibalizumab-uiyk, 10 mg19.921
Inj, spesolimab-sbzo, 1 mg19.726
Leuprolide acetate /3.75 mg18.534
Inj leu acet lutr dpt 7.5 mg16.148
Inj, meropenem (b. braun)9.704
Inj, mirikizumab-mrkz, 1 mg16.789
Naltrexone, depot form19.876
Palifermin injection16.509
Inj, pasireotide long acting15.043
Pegloticase injection19.433
Inj, romiplostim 1 microgram18.328>
Injection, siltuximab18.032
Inj. eptinezumab-jjmr 1 mg19.160
Inj talquetamab-tgvs 0.25 mg19.445
Inj tedizolid phosphate19.782
Tenecteplase injection19.199
Inj. romosozumab-aqqg 1 mg18.911
Testosterone undecanoate 1mg18.576
Triamcinolone a inj prs-free3.892
Inj., triptorelin xr 3.75 mg19.559
Xyntha inj19.499
Antithrombin iii injection19.776
Inj. jivi 1 iu19.429
Inj, kovaltry, 1 i.u.19.923
Tacrol envarsus ex rel oral19.657
Lymphocyte immune globulin11.283
Oral netupitant, palonosetro18.352
Inj, aspara, rylaze, 0.1 mg19.459
Injection, belinostat, 10mg19.738
Injection, blinatumomab18.259
Brentuximab vedotin inj17.939
Injection, carfilzomib, 1 mg17.843
Inj, amivantamab-vmjw18.669
Daratumumab, hyaluronidase19.924
Injection, daratumumab 10 mg19.807
Inj daunorubicin, cytarabine19.424
Inj enfort vedo-ejfv 0.25mg19.401
Inj gemcitabine hcl (accord)18.430
Ixabepilone injection19.748
Pegaspargase injection18.591
Pentostatin injection18.535
Inj. tagraxofusp-erzs 10 mcg19.516
Inj tisotu vedotin-tftv, 1mg19.165
Inj pemetrexed (sandoz) 10mg15.508
Panitumumab injection18.227
Injection, pertuzumab, 1 mg19.500
Pralatrexate injection19.377
Inj pemetrexed (teva) 10mg18.512
Inj talimogene laherparepvec18.748
Inj. margetuximab-cmkb, 5 mg19.994
Inj, ado-trastuzumab emt 1mg19.870
Inj fam-trastu deru-nxki 1mg19.873
Inj teclistamab cqyv 0.5 mg19.759
Axicabtagene ciloleucel car+18.187
Tisagenlecleucel car-pos t17.633
Brexucabtagene car pos t19.819
Lisocabtagene mara car pos t18.170
Idecabtagene vicleucel car18.751
Ciltacabtagene car-pos t18.863

Source: CMS.gov

How Much Could Beneficiaries Save on These Prescriptions?

According to 2024 CMS Administrator Chiquita Brooks-LaSure, “As we head into 2025, people with Medicare will feel substantial relief from high drug prices. In addition to lower cost-sharing for certain drugs whose prices have increased above the rate of inflation, people with Medicare prescription drug coverage will have their annual out-of-pocket costs capped at $2,000 for the first time. This will be life-changing for people who have been living with high drug costs.”

It’s important to note that specific savings will depend on the individual and their exact coverage.

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For more info on the Medicare Prescription Drug Rebate Program, visit CMS.gov/inflation-reduction-act-and-medicare/inflation-rebates-medicare.

Not affiliated with or endorsed by Medicare or any government agency.

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